Gundelia tournefortiiAntidiabetic Efficacy: Chemical Composition and GLUT4 Translocation
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چکیده
منابع مشابه
TUG cleavage regulates GLUT4 translocation Endoproteolytic cleavage of TUG regulates GLUT4 glucose transporter translocation*
Jonathan S. Bogan, Bradley R. Rubin, Chenfei Yu, Michael G. Löffler, Charisse M. Orme, Jonathan P. Belman, Leah J. McNally, Mingming Hao, and James A. Cresswell From the Section of Endocrinology and Metabolism, Department of Internal Medicine, and Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520-8020 Running head: TUG cleavage regulates GLUT4 translocation Add...
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Skeletal muscle is the major tissue for postprandial glucose disposal. Facilitated glucose uptake into muscle fibers is mediated by increases in surface membrane levels of the glucose transporter GLUT4 via insulin- and/or muscle contraction-mediated GLUT4 translocation. However, the regulatory mechanisms controlling GLUT4 translocation in skeletal muscle have been difficult to characterize at t...
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A number of studies have demonstrated that insulin resistance in the skeletal muscle plays a pivotal role in the insulin resistance associated with obesity and type 2 diabetes. A decrease in GLUT4 translocation from the intracellular pool to the plasma membranes in skeletal muscles has been implicated as a possible cause of insulin resistance. Herein, we examined the effects of an insulin-sensi...
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In fat and muscle cells, insulin stimulates the movement to and fusion of intracellular vesicles containing GLUT4 with the plasma membrane, a process referred to as GLUT4 translocation. Previous studies have indicated that Akt [also known as PKB (protein kinase B)] phosphorylation of AS160, a GAP (GTPase-activating protein) for Rabs, is required for GLUT4 translocation. The results suggest that...
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In skeletal muscle and adipose tissue, insulin-stimulated glucose uptake is dependent upon translocation of the insulin-responsive glucose transporter GLUT4 from intracellular storage compartments to the plasma membrane. This insulin-induced redistribution of GLUT4 protein is achieved through a series of highly organized membrane trafficking events, orchestrated by insulin receptor signals. Rec...
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ژورنال
عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine
سال: 2018
ISSN: 1741-427X,1741-4288
DOI: 10.1155/2018/8294320